Iron Toxicity Post #67: There is 5 TIMES MORE IRON in Breast Cancer cells than Normal cells…

by Morley Robbins on February 17, 2018

MAG-pie & MAG-net Alert!…

Iron Toxicity Post #67: There is 5 TIMES MORE IRON in Breast Cancer cells than Normal cells…

I’m confident that MANY will NOT like what this Post has to say. Quite frankly, even I was STUNNED by the compelling Cancer research that I stumbled upon (was guided to?!?… 😉 ) earlier this week.

But BEFORE you settle into this hard-hitting post, I’d like you to witness the combined impact of H2O2, Ascorbic Acid AND Iron Sulfate… This brief video was brought to my attention by @Ben Edwards, MD, my UBER-gifted clinician and “step-down-transformer,” who had received it from one of his gifted ND practitioner buddies…

Please be sure to be sitting down when you watch it… it makes QUITE the statement!

https://www.youtube.com/watch?v=-V27uNpGR6c

I’m confident that those who are regulars on MAG FB Group “get it,” and that you are totally “on-board!” The video, however, is a compelling example of the “Iron-ic Dynamics” that we’re seeking to better understand and bring under BETTER control INSIDE OUR BODIES… Please know, that this is a reaction that can take place INSIDE our cells…

Now what may surprise you is that even with ALL that I’ve shared and written about, that even I have a smidgeon of doubt – from time-to-time — that this “Iron-thingy” is the SOLE metabolic issue, and that this “RCP-thingy” is the SOLE anti-dote to that Iron-induced chaos. AFTER INTERNALIZING THE RESEARCH this week, I have absolutely NO DOUBT! My resolve is now locked in…

During my morning research ritual earlier this week, I happened upon a recently released textbook (2014) entitled: Cancer: Oxidative Stress and Dietary Antioxidants edited by Victor R. Preedy, PhD,
https://www.amazon.com/Cancer-Oxidative-Stress-Dietary-Antioxidants-ebook/dp/B00IYGRI5W

a distinguished professor of nutritional biochemistry at King’s College in London, England. I’ve read other articles and research by Dr. Preedy, but none on Cancer. (And as my typical ritual, I called to thank him for this amazing body of knowledge… )

The material that I’m sharing in this email is from Chapter 13 entitled “Iron Homeostasis & Cancer Development: Mechanistic Views” which is co-authored by two gifted Korean Iron researchers: Mi-Kyung Sung, PhD, and Yun-Jung Bae, PhD. Here are the KEY findings that captured my attention:

 

  • “A recent in vitro study suggested that Iron-induced ROS generation was facilitated by the increased HO-1** (Heme Oxygenase-1) activity resulting in increased expression of MMP-1 (Matrix Metalloproteinase-1) in human breast cancer cells. [46] MMPs are a group of proteinases involving Cancer Cell migration and Angiogenesis*** that indicates a possible involvement of Iron overload with cancer metastasis.[46] Kim DH et al, 2009, “15-Deoxy-Delta12,14-prostaglandin J2 upregulates the expression of Heme Oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: Possible roles of Iron and ROS”
    Abstract: https://www.ncbi.nlm.nih.gov/pubmed/19136476

Now, PLEASE STOP READING this Post, and study the Attached Table 1 below that outlines the amount of Iron vs Other metals found in Breast tissue – tumor cells vs normal cells…

Do you HONESTLY think that this Iron concentration within Cancer cells ONLY occurs in Breast Tissue?!?… And given that Breast Cancer is a known form of “Estrogenic Cancer,” we can certainly conclude that this Iron presence is a safe bet for ALL Estrogenic Cancers. And it certainly seems to seal the deal for the Iron <> Estrogen connection that is found in those with LOW Bioavailable Copper…

What I will add, however, is that the Research on the connection between Iron-induced metabolic CHAOS and Cancer is growing daily… Please take command of this IRON-ic & OBVIOUS Environmental and EPIGENETIC “Metal-bolic” factor that is at the CORE of Cancer metabolism…

And given the century old awareness that Scientists & Clinicians have had about the Fenton Reaction (discovered in 1894…) between Ferrous (Fe2+) Iron and H2O2, it is important to begin to understand the PROFOUND impact that this Hydrogen Peroxide Oxidant has in our bodies and in our metabolism…

What I want to NOW point out is the CENTRAL role that H2O2 plays in THREE KEY areas highlighted in the Research above and noted with asterisks:

  • * H2O2 Stimulates TfR-1 (Transferrin Receptor-1) to increase the uptake of Iron, over-riding the IRP/IRE Regulatory Pathway… (as referenced in the article that I posted recently noting that H2O2 Fuels Aging, Inflammation & Cancer…)FOLKS, this is HOW Iron BUILDS inside our cells!…
  • ** H2O2 Increases the expression of HO-1 (Heme Oxygenase-1) enzyme, which means that Hemolysis [RBC turnover…] is accelerated in H2O2-rich conditions, i.e. in states of Inflammation, as there is a constant release of H2O2 by Inflammatory cells… (I would assert that this is likely greatest with Iron-laden Macrophages that become M1- or M2-Polarized in their immune function, and are now being identified as a major contributing factor to the 30+ Autoimmune conditions…)FOLKS, chronic states of H2O2 production are the devastating byproduct of Inflammation…
  • *** H2O2 is a key agent to stimulate Angiogenesis, and we can now add that it stimulates the migration, i.e. metastasis, of Cancer cells via MMPs and their impact on EMT (Endothelial-Mesenchymal Transition)…FOLKS, this Iron-induced H2O2 becomes a KEY mechanism to enable Angiogenesis & Metastasis that are HALLMARKS of tumor growth & proliferation…

Please know, I am beginning to compile a BROAD & DEEP set of facts re Iron <> Inflammation <> H2O2 interaction that has pervasive metabolic dysfunctions, which is enough to bogle the mind… In addition to the above, it is worth noting that Iron-induced H2O2 production was the VERY agent for Lipid Peroxidation in our Arteries & Aorta in the 1950’s & beyond, that was NEVER revealed while the nation & the World was taken hostage by Low Fat & Cholesterol-free diets that were forced upon us by Ancel Keys, PhD, lo these 60+ years ago…

Cholesterol by itself was NEVER the problem… It was the FACT that in the presence of Iron & thus H2O2, that increased Cholesterol being produced in our Iron-laden/Copper-deficient Livers GETS RUSTY – and it’s called “Coronary Arterial Plaque,” but it’s RUST, NONETHELESS!

The one aspect of this Cancer information that might be worth considering is that treating cancerous tumors with Ascorbic Acid, while increasingly favored and worthwhile as it overwhelms the cancer cells with Oxidative Stress, it hardly seems enough or complete given the OBVIOUS NEED to address the prevalence of Iron.

It is CLEAR AND COMPELLING that we ALSO want to be engaging in a full-scale chelation of Iron with Desferoxamine or related chelating agents when in the throes of seeking to resolve these cancerous conditions. It would seem that there is more than adequate justification for this two-pronged approach to assist practitioners in resolving Cancer metabolism within their patients’ bodies…

So, there you have it…

The numbers are in, and the evidence is incontrovertible!… Table 1 below is watershed evidence that there is WAAAAAAAY MORE to this Cancer dynamic than we were EVER told. I think it is HIGH TIME that we ask BETTER questions and seek BETTER options than we’ve been given in the past… And it is HIGH TIME that we come to ACCEPT the central and causative role that Iron plays in metabolic dysfunction and mineral dysregulation…

I’ll leave it at that, and wish you the best as each of you ponder the implications of this research…

A votre sante!
Morley M. Robbins
gotmag,org

And, the new video series is here!
The Root Cause Protocol

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