Iron Toxicity Post #65: Welcome to my world of relentless blah-blah-blah about how Iron “regulates” itself…
I’m sharing the musings of just ONE day of my efforts to research Iron, and what’s posted below is ONLY ½ of what I found… 😉
I am forever amazed at the lengths that Iron Researchers will go to to slice & dice their findings & insights, but OVERLOOK the MOST IMPORTANT FACT.
In these 9 Articles – and there are 100’s more just like them — that “examine” the many facets of Iron Metabolism and Iron Homeostasis, there is ONE WORD that is missing from ALL of these studies… Any one want to venture a guess as to what that one word might be?!?…
Yes, that word would be COPPER… MAG me with a spoon!
Yes, they make a point of mentioning Ceruloplasmin, and on a rare occasion, will discuss the Ferroxidase enzyme function, but no where do they honor or highlight that there is NO such thing as “Iron Metabolism.” There is ONLY Copper<>Iron Metabolism, and as I’ve noted MANY, MANY, MANY times, Iron is, for a fact, the DUMMY in that metallic Tango!… Despite what you read on the Internet, please trust me, Iron takes its cues from Bioavailable Copper. SOLELY…
And what is MOST important to understand is that Iron is NOT designed to be “In Storage!” 80% of the Iron in your body is found in Hemoglobin & Myoglobin, which is in constant circulation. <10% is found in Ferritin and THAT is meant to be INSIDE the Cell, NOT inside your Serum!
The study by Vanoaica, et al (2010) is unique in its recognition that Ferritin-H is ESSENTIAL for “accurate control” of Iron. And what is Ferritin-H (Heavy) Chain?… It’s a form of Ferritin that has Ferroxidase enzyme function, which is ESSENTIAL for proper Iron egress & circulation… (They’ve KNOWN this since 1968!)
And before you get too excited, NO, your doctor has NO way to distinguish this form of Ferritin from the Ferritin-L (Light) Chain. You would think that they would, but alas, we are left with the Mushrooms… in the dark & buried in compost!… In your NEXT life you’ll want to come back as a 4-legged RAT, so that you’ll know FOR CERTAIN what you’re Ferritin fractions are, as these two tests are done ALL THE TIME in the Research Labs… 😉
o Chen C & Paw BH, 2012-Jan18, “Cellular and Mitochondrial Iron Homeostasis in Vertebrates,” Biochima & Biophysica Acta(BBA) – Molecular Cell Research
https://www.sciencedirect.com/…/artic…/pii/S0167488912000055
o Anderson CP et al, 2012-Sep, “Mammalian iron metabolism and its control by iron regulatory proteins”
Biochimica & Biophysica Acta (BBA) – Molecular Cell Research 1823(9):1468-1483 https://doi.org/10.1016/j.bbamcr.2012.05.010
https://www.sciencedirect.com/…/artic…/pii/S0167488912001267
o Hentze MW et al, 2010-July9 2010, “Two to Tango: Regulation of Mammalian Iron Metabolism” Cell; 142(1):24-38
https://doi.org/10.1016/j.cell.2010.06.028
http://www.sciencedirect.com/…/article/pii/S009286741000718X
o Kuhn LC, 2009-Dec2, “How Iron Controls Iron” Cell Metabolism 10(6): 439-441
http://www.sciencedirect.com/…/article/pii/S1550413109003428
o Ganz T, 2008-Apr9, “Iron Homeostasis: Fitting the Puzzle Pieces Together” Cell Metabolism 7(4): 288-90
https://doi.org/10.1016/j.cmet.2008.03.008
http://www.sciencedirect.com/…/article/pii/S155041310800079X
o Simpson RJ et al, 2009-Aug6, “Regulation of Intestinal Iron Absorption: The Mucosa Takes Control?” Cell Metabolism 10(2):84-87
https://doi.org/10.1016/j.cmet.2009.06.009
http://www.sciencedirect.com/…/article/pii/S1550413109001892
o Andrews NC, 2010-Sep8, “Ferrit(in)ing Out New Mechanisms in Iron Homeostasis” Cell Metabolism 12(3)-203-204
https://doi.org/10.1016/j.cmet.2010.08.011
http://www.sciencedirect.com/…/article/pii/S1550413110002792
o Vanoaica L et al, 2010-Sep8, “Intestinal Ferritin H Is Required for an Accurate Control of Iron Absorption” Cell Metabolism 12(3):272-283
https://doi.org/10.1016/j.cmet.2010.08.003
http://www.sciencedirect.com/…/article/pii/S1550413110002688
o Thompson JW et al, 2012-Sep, “Protein degradation and iron homeostasis” Biochimica & Biophysica Acta (BBA) – Molecular Cell Research 1823(9):1484-1490
https://doi.org/10.1016/j.bbamcr.2012.02.003
http://www.sciencedirect.com/…/article/pii/S0167488912000328
And what these many studies are seeking to reveal is that the regulation of Iron relies on two KEY pathways for optimal Iron circulation & R.E.cycling:
o Ferroportin<>Hepcidin System, but they are SILENT on the fact that this System does NOT work without Bioavailable Copper in the form of Ferroxidase enzyme function…
o Iron Regulatory Proteins (IRP1-2) and Iron Response Elements (IREs) System, but they are SILENT on the fact that this System responds EQUALLY well to Retinol (Animal-based Vitamin-A) JUST AS WELL as is does to Iron supplementation… And what is FASCINATING about that ^^^^ factoid is that Retinol is KEY & FOUNDATIONAL for the synthesis of Ferroxidase enzyme need above… Hmmmmmmmmm…
C’mon now, don’t you find that just a tad bit entertaining?…
Folks…
We are “D”rowning in Hormone-D supplements – that KILL Retinol status in the Liver!…
We are “D”rowning in Iron Supplements & Infusions – that KILL our metabolism!…
We are “D”rowning in Zinc Supplements that CAUSE Copper to be bound up, and NOT available…
We are “D”rowning in Ascorbic Acid Supplements that INCREASE H2O2 (which TWEAKS the Ceruloplasmin protein & KILLS the Ferroxidase function) and ACCELERATES Iron STORAGE…
Am I the ONLY one seeing a predictable pattern here with the nutritional practices of allopathic & alternative practitioners?…
I wish it weren’t THIS OBVIOUS & THIS CLEAR…
And just wait until I share the OTHER ½ of today’s research that states – DEFINITIVELY — that Cancer is CAUSED by IRON… I almost fell out of my chair earlier today!
Better MAG UP, and be prepared for the next Iron Toxicity Post!…
A votre sante!
Morley M. Robbins
gotmag.org
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