This is Iron Toxicity Post #66: “Iron and the RBC (Red Blood Cell): Is this where the ASSAULT begins?” (OMg!… Does a Bear SLEEP in the Woods?!?)
Dr. Liz and I just watched the new movie on P.T. Barnum: “The Greatest Showman.” It’s definitely worth your time to witness the captivating story behind the indominable spirit and imagination of this amazing figure in our entertainment past. The movie ended with one of the most famous quotes attributed to him:
“The noblest art is that of making others happy.”
I REALLY like that sentiment, but I’m going to go ONE STEP further, and paraphrase it…
“The noblest act is teaching others how to be healthy.”
(I intend to “adopt” that statement as my signature effort in this lifetime…)
Quite frankly, I’m sick & tired of folks being “sick & tired!” And I am devoting the rest of my days to helping MAG-pies & MAG-nets on this Planet to get EDUCATED & to get EMPOWERED on the KEY steps that need to be undertaken to RE-STORE Metabolic Balance in their bodies. It is NOT Rocket Science!
I should add that I am hardly alone in this effort, and among my many “mentors” that have helped shape and mold my thinking about these key requirements is Jerry Tennant, MD (Dallas, Texas), recently praised with a Lifetime Achievement Award at the “Doctors Who Rock” symposium in Florida. He is also the noted author of “Healing is Voltage,” among other books, which is a MUST read for anyone wanting to UNDERSTAND the wiring of the human metabolism, and the VITAL importance of cellular energy production to assure optimal cellular frequency, and thus optimal health.
It’s worth knowing that what inspired Jerry Tennant, MD, at the depths of his 7-yr long illness crisis, was the fervent belief that if he could get ONE CELL in his body to work, then he could get them ALL to work!… (I should add, this focus is akin to the thinking of a gifted mechanic that I worked with, named Otis, one summer while on break from college… He was convinced that if he could get ONE Cylinder in the engine to work, he could get them ALL to work…)
Given that FOCUS, what then do I regard as the MOST IMPORTANT cell in the human body?…
Well, I would argue that it’s the Erythrocyte, aka the Red Blood Cell, or RBC… It’s been on my radar screen for ~8 years!
OK, here are some KEY FACTS that highlight the importance of this ubiquitous & largely overlooked cell in our body:
- There are some 20-30 Trillion RBCs in the average adult…
- In one small drop of blood (1 cubic mm) there are 4-5 Million RBCs…
- RBCs account for ~84% of ALL Human Cells… (please let that % sink in before dashing to the NEXT line… 😉 )
- RBCs, by virtue of being created inside the bone marrow, are considered CONNECTIVE Tissue… (Again, please let the significance of that FACT sink in… )
- Each Human RBC (Red Blood Cell) contains ~250-270 Million Hemoglobin molecules…
- There are 4 Heme proteins contained in EACH molecule of Hemoglobin, and each has an atom of Iron in the center… (not unlike a Ceiling Fan in the center of your Den or Living Room…)
- Each Human RBC (Red Blood Cell) can carry 1 Billion Oxygen (O2) Molecules… (And if Iron is misbehaving, that’s A LOT Oxygen molecules to CREATE potential RUST, folks…)
- 70 % of ALL Iron contained in the human body is found in those Zillions & Zillions of Hemoglobin
- The oft-quoted IDEAL Lifespan for these RBCs (Red Blood Cells) is ~120 days…
- The rate-limiting enzyme to determine the energy, viability & thus Lifespan of these RBCs is G6PD enzyme, aka Glucose-6-Phosphate Dehydrogenase… (It’s the head of the stream of the Pentose Phosphate Pathway…)
- “G6PD deficiency” is regarded at the GREATEST enzyme deficiency on this Planet… It’s worth noting that this enzyme has relationships with BOTH Magnesium and Bioavailable Copper…
- When RBCs get “Stressed!” and can’t make PROPER energy, they lose their flexibility, and energy-driven shape, and then get “flagged” for RE-CYCLING, aka “Hemolysis.”
- In separate studies, either Copper deficiency OR Magnesium deficiency CAUSES the RBC lifespan to DROP 80%… to ~20 days! That is an EXTRAORDINARY LOSS OF LIFESPAN, AND AN EXTRAORDINARY ACCELERATION of RBC Turnover!
- This ^^^^ is the VERY METABOLIC MECHANISM that leads to Iron-laden Macrophages that RESULTS IN ALL AUTOIMMUNE CONDITIONS…
- It is worth REPEATING that the synthesis of Heme, the insertion of Iron into Heme, the knitting of four Heme to make ONE Hemoglobin molecule, as well as the regulation of HO-1 (Heme Oxygenase-1) “re-cycling” enzyme ALL REQUIRE BIOAVAILABLE COPPER…
- And where does “Oxidative Stress!” and “Inflammation” START in our bodies?!?… RIGHT HERE in the RBCs (Red Blood Cells) of our blood…
- And MOST IMPORTANTLY, please remember that Iron simply CARRIES Oxygen throughout the body, but FOR A FACT, COPPER is the ONLY mineral that can USE/ACTIVATE Oxygen to release Energy or change chemicals (e.g. Neurotransmitters) in the body – and that’s a MAJOR BIG DEAL that is LOST in the world of conventional “you need MORE Iron” medicine…
Given ALL OF THIS ^^^^, doesn’t it make sense to START the process of understanding how to STOP the Oxidative CHAOS that originates INSIDE the RED BLOOD CELLS?!?…
Call me goofy, but this seems to me like a PENETRATING LOOK INTO THE OBVIOUS… Thankfully, I am NOT alone in this thought, as it has been a MAJOR focus of research for many decades. Regrettably, NONE of these findings about the importance and the fragility of the RBC (Red Blood Cell) seems to be taught at ANY school of health practitioner training anywhere on the Planet in this “modern era.”
Here are some noted studies that offer KEEN insights to this Iron <> RBC foundational premise:
Clemens MR et al, 1987, “Lipid Peroxidation in Erythrocytes”
https://www.ncbi.nlm.nih.gov/pubmed/3319229
“Most of the protective activity [for RBCs] is associated with two proteins, transferrin and Ceruloplasmin.” As has been noted before, Iron require CONSTANT supervision or chaperoning, not unlike a 4-yr old with a Hammer!
Neven E et al, 2011, “Iron & Vascular Calcification: Is There a Link?”
https://academic.oup.com/ndt/article/26/4/1137/1884318
Figure 1 of this seminal assessment of Iron-induced calcification of patients with CKD is stunning. The fact that RBCs are considered “connective tissue” and have osteogenic [bone-making] properties is a GAME CHANGER in terms of the recognized stimulatory role of excess, unbound Iron in TRIGGERING & FOSTERING both Plaque (Atherosclerosis) and Hardening of the arteries (Arteriosclerosis), as well as Calcification of Organs throughout the body…
Jeney V et al, 2014, “Red blood cell, hemoglobin and heme in the progression of atherosclerosis”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183119/
“Neovascularization is induced mostly by Hypoxia [lack of Oxygen, but ALSO lack of the ability to USE Oxygen…] but the involvement of Oxidative Stress is also established.” And when the speed of Hemolysis accelerates, the protective proteins to guard Hemoglobin [Haptoglobin] and Heme [Hemopexin] are simply used up!
Zarjou A et al, 2010, “Ferritin Ferroxidase Activity: A Potent Inhibitor of Osteogenesis”
http://onlinelibrary.wiley.com/doi/10.1359/jbmr.091002/full
“… osteogenesis and pathogenesis of Iron caused bone defects, and by exposing ferritin as the cause of decreased OB (Osteoblast) maturation…” The Excess of Iron is the TRUE “bad boy” in Osteoporosis, and the role of Ferritin is key, esp. when it has Ferroxidase enzyme function…
Vercellotti GM et al, 2014, “H-Ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis”
https://www.frontiersin.org/articles/10.3389/fphar.2014.00079/full
“We conclude that wt-hFHC (wild type-human Ferritin Heavy Chain) Ferroxidase activity enhances cytoprotective Nrf-2-regulated proteins, including HO-1, thereby resulting in decreased NF-kB activation [KEY marker for Inflammation], adhesion molecules, and microvascular stasis in transgenic SCD [Sickle Cell Disease] mice.” Once again, Ferroxidase enzyme function PROTECTS via its “Anti-Oxidant” properties and functions throughout the body…
So, what’s the bottom line?…
We are left LOST in the Byzantine world of allopathic blood testing. There are NO TESTS for:
- Ferroxidase enzyme function (Ceruloplasmin is a proxy, but NOT the real deal…)
- No distinction between Ferritin- Heavy Chain vs Ferritin Light Chain, and NO assessment of EITHER in Intracellular Ferritin!
- Oxidized LDL (Low Density Lipid) Cholesterol, a KEY marker for Oxidative Stress in the blood
- NEITHER Haptoglobin, NOR Hemopexin are measured, which are KEY to protecting Hemoglobin and Heme, respectively in the blood, as noted above…
- No marker for Hemosiderin, otherwise known as “de-natured” Ferritin from too much H2O2…
- No marker for RBC Lifespan to better understand the rate of Hemolysis (RBC Turnover…)
- No marker for H2O2 (Hydrogen Peroxide), which is a MAJOR Oxidant to cause RBC CHAOS…
- No easily accessed marker for assessing Iron status INSIDE the Red Blood Cell, where it matters MOST…
- No easily accessed marker for Erythrocyte SOD, the MOST sensitive marker for the bioavailability of Copper in the Human body…
Trust me, I could go on, and on, and on, and on with the limitations of conventional Iron testing…
I think you get the point at this point in the process. The healthier our RBCs (Red Blood Cells) are, the healthier we are. The potential for Oxidative assault in our blood that is largely overlooked is quite significant. And THAT’S WHY we obsess over the level of Magnesium in the RBC… Isn’t it ODD that no doctor that you’ve EVER been to has EVER tested for this seminal mineral inside this seminal blood cell?… Personally, I find that fact ALONE, STAGGERING and INCRIMINATING. And in light of the research shared above ^^^^, you should, too!
Please know, the better REGULATED by Copper, and the better CHAPERONED by proteins our Iron is, the LESS LIKELY we are to be subjected to Oxidative Stress and/or Inflammation. The Research is QUITE clear about that, following FOUR years of intensive study on that ONE dynamic alone!
So, the Root Cause Protocol has particular relevance and reason for its health-enhancing impact. Please KNOW that…
And I’ll leave you with one LAST quotation from P.T. Barnum:
“The foundation of success is good health.”
He was the consummate “Showman,” but I would offer that he was also a GREAT “Sha-man!”
A votre sante!
Morley M. Robbins
gotmag.org
And, the new video series is here!
The Root Cause Protocol
