MAG-pie Alert!… #23 TOXICITY OF IRON
MAG-pie & MAG-net Alert!
I’d like to present a more succinct logic for how Iron dysregulation & Mg deficiency are at the heart of MOST, if not all, of our chronic conditions…
Here is my premise in a nutshell:
Inc. Dietary & Supplemental Iron >> Inc. Magnesium Deficiency >> Inc. Oxidative Stress! >> Inc. Protein Oxidation >> Inc. Protein Carbonyls >> Inc. Chronic Disease (that are often labeled as Neurodegenerative Disease, Heart Disease, Liver Disease, Kidney Disease, Cancer, etc.)
WARNING: For those looking for “fast & easy,” this Post AIN’T it… However, what this series of summary comments and citations does do is explain WHY “Mag-neto Man!” is fundamentally gaa-gaa over Magnesium and Ceruloplasmin…
o Increased Dietary & Supplemental Iron:
OK, this AIN’T “academic,” but it’s a compelling piece on how all this Iron-ic insanity started and has been building for 70+ years…
https://freetheanimal.com/2015/06/enrichment-theory-everything.html
If you want a more “academic” piece, the University of Chicago should suffice:
http://web1.sph.emory.edu/users/hpacho2/PartnershipsMaize/Bishai_2002.pdf
o Increased Iron leads to Magnesium deficiency:
http://www.ncbi.nlm.nih.gov/pubmed/8907021
(Please read the LAST sentence of this abstract SLOOOOOOWLY…)
o Increased Oxidative Stress & Protein Oxidation from all that Iron:
This is the recognized “go to” citation for those topics:
http://www.biochemj.org/content/ppbiochemj/219/1/1.full.pdf
(I’m reading their book on these metabolic processes from 1994, and it’s a genuine “toe-curler… 😉 )
o Increased Protein Carbonylation from all that Iron:
http://repositorio.uchile.cl/bitstream/handle/2250/127165/Cornejo_P.pdf?sequence=1
NOW HERE’S WHERE IT GETS REALLY INTERESTING…
o Magnesium Deficiency INCREASES Protein Carbonyls:
Trust me, that is NOT what we’re seeking in our bodies, our tissues, and our cells. Here is the relevant abstract:
http://www.ncbi.nlm.nih.gov/pubmed/8240333
(And if you can prove you’re NOT a robot, here’s the link to get the full article: And please say a prayer of thanks for Wm. B. Weglicki, MD and his research team at GWU Medical Center…
http://anothersample.net/order/288a0bce143e905836c54fe1cbff1e4c07dda935)
o AND here’s the OTHER side to this “D”estructive Oxidative Process:
Ceruloplasmin (Cp) INHIBITS Protein Carbonyl Formation:
http://www.ncbi.nlm.nih.gov/m/pubmed/8425718/
Ceruloplasmin (Cp) is the MOST myth-understood protein in the human body. It is OFTEN referred to as a “Taxi” for Copper… However, in fact, it’s more like a “Tank!” that has 8 Copper atoms running it… it doesn’t take military experience to know that there is a MAJOR difference between those two modes of “transportation…”
o One last thought…
Know that Ceruloplasmin (Cp) is subject to “oxidation” (aka “aging…”), and that this is NOT a good thing for our overall health & well-being… But in this COMPELLING study, they make it VERY clear that Cp Oxidation is the CAUSE of ALL Nerurodegenerative conditions — yes, but hardly limited to dysfunctions & disorders of JUST the Brain…– as the “aging of Cp” INHIBITS it’s elegant Ferroxidase activity, AND, in fact, promotes cellular Iron retention:
http://www.jneurosci.org/content/31/50/18568.full
(You might want to re-read that LAST sentence, again… 😉 )
So please know that these Iron-induced processes are NOT just restricted to Rats and other lab critters. Imho, this “Iron dysregulation” condition is a PANDEMIC on this Globe and knows no geographic boundaries…
Hopefully, this Post can serve as a “go to” piece for those who are seeking to BETTER understand & BETTER explain what all these Iron-ic switchbacks and inter-Iron-dynamics are all about… And, yes, Iron metabolism is supremely confusing, but know that there is a powerful body of extensive research to support and expound upon each of the citations referenced above… (And ALL of the gifted Iron researchers KNOW how essential bioavailable Copper is to ALL facets of Iron metabolism…)
So what’s this got to do with MAG (Magnesium Advocacy Group on FB)?
MAG is ALL about restoring metabolic balance in our cells, our tissues and our bodies. That healing process necessitates LOWERING the Iron burden, enhancing the Liver/Brain’s natural production of the Copper powerhouse, Ceruloplasmin (Cp), and restoring mineral & Magnesium balance to PREVENT the Oxidative Stress from happening in the 1st place. Clearly, there are numerous processes involved, but that’s the CORE focus of our strategy. (At least we have one… )
And I would venture to say that we are UNIQUE in our focus here at MAG and are very proud of our collective track-record for identifying and addressing the underlying nutrient deficiencies and overloads that have historically and continue to keep us OFF-BALANCE…
Hope this overview ^^^^ helps. I’ll look forward to the blow-back & chatter that these thoughts will likely generate…
A votre sante!
MORLEY M. ROBBINS
Read More at Magnesium Advocacy Wall:
https://www.facebook.com/groups/MagnesiumAdvocacy/permalink/973984906002912/
LivefoodDtox interview with Morley Robbins – EXCESS, UNBOUND IRON
