MAG-pie and MAG-net Alert!…
Post # 25 in the Iron <> Copper Dynamics…
Famous Buddhist saying:
To the common person, mountains are mountains and rivers are rivers…
To the person with education, mountains are NO LONGER mountains and rivers are NO LONGER rivers…
But to person with wisdom, mountains are mountains and rivers are rivers…
We’re ALL getting a bit fatigued at these posts and this relentless topic… Trust me, I get that, but I want to bring what I believe is an important set of articles together to drive home a KEY point about Iron metabolism…
It turns out that Red Blood Cell metabolism, and by inference, Iron metabolism, are among the MOST sophisticated re-cycling programs on this Planet. Iron in MOTION is a great thing. Iron is STORAGE, however, is the basis for “rust,” or Oxidative Stress as it’s called in the highbrow scientific literature.
What I came across this morning during my daily vigil with the research was this penetrating study by Baker and Ghio, 2009, “Iron Homoeostasis in Rheumatic Disease:”
http://m.rheumatology.oxfordjournals.org/content/48/11/1339.full.pdf
** NOTE: THIS STUDY ^^^^ MAY BE AMONG THE MOST IMPORTANT I’VE SHARED RE THIS IRON-IC TOPIC**
There are some penetrating insights provided by these two gifted Iron researchers, despite the contemporary, habitual pattern of dissing Ceruloplasmin (Cp) in the process of ensuring optimal Iron metabolism. As expected, the spotlight is put on the ever-popular Hepcidin, the recently anointed Iron Hormone that has a whopping 25 amino acids. (As Dr. Liz’s Dad used to say, “Big spider… )
Please note: Cp has 1,056 Amino Acids, 8 Copper atoms and is a metabolic powerhouse in our bodies as I’ve stressed previously…
What I’d like you to walk away with is some IRON WISDOM in this Post…
In my opinion, the study by Baker & Ghio is a bit of revisionist history about who’s key to making Iron mobile. And I truly believe that this is where the train comes OFF the tracks and creates the pervasive confusion surrounding this metal in the human body…
If you get nothing else from this Post, please remember that Ceruloplasmin’s GIFT is Iron mobilization… Cp ENSURES that Iron gets properly attached to Transferrin so that it can, in fact, be transported properly & effectively to the cells and the tissues seeking this metal for our metabolism. THAT IS KEY…
This TRUTH of Ceruloplasmin has been KNOWN since 1969:
http://www.jbc.org/content/244/20/5757.full.pdf+html
(This seminal study by Osaki & Johnson is one of the MOST cited studies in the EARLY research on Iron & Cp… Regrettably, that is NO LONGER the case…) Yes, Virginia, there is politics in research, and yes, there is an agenda… Sorry to burst your bubble… wink emoticon
Now to get a handle on the scope and reach of bioavailable Copper, MADE POSSIBLE BY Cp, please read this compelling chapter by Gary W. Evans, PhD from 1977:
http://naldc.nal.usda.gov/download/45180/PDF
(Yes, I understand… it’s ANCIENT history, but isn’t the WISDOM found with our Elders?…)
Please pay particular attention to the KEY ENZYMES noted on Pg 169 — it’s a vertible “Who’s Who” of critical metabolic chemicals that WILL NOT WORK without bioavailable Copper, and when that’s the case, these enzyme dysfunctions lead to SCORES, and SCORES of symptoms, that then get labeled & treated, but NEVER cured…
So what’s my point?…
Please study Figure 2 (Page 172 of Evans Chapter) to FULLY UNDERSTAND how Cp enables proper loading of Iron onto Transferrin, which is what ensures the MOBILIZATION of Iron…
AGAIN, the objective of Iron metabolism is MOBILIZATION. And Cp is the metabolic agent to GUARANTEE that functional requirement is met.
The object is NOT TO STORE Iron. That is outrageously out of touch with the WISDOM of the body…
And for those seeking to gain a broader and more contemporary understanding of these dynamics between Iron, Hepcidin and Ceruloplasmin, here are a few studies that you’ll no doubt find enlightening:
o Loreal, 2014: http://journal.frontiersin.org/article/10.3389/fphar.2014.00128/full
o McCarthy, 2014: http://www.ncbi.nlm.nih.gov/pubmed/24533165
o Kwapisz, 2010: http://journal.frontiersin.org/article/10.3389/fphar.2014.00128/full
o Kono, 2010: http://www.ncbi.nlm.nih.gov/pubmed/20655381
o Troadec, 2008: http://www.sciencedirect.com/science/article/pii/S0925443907002396
I do apologize for the length and the # of articles being cited…
This dynamic of Iron metabolism is NOT Grade school Math! Simple Ferritin-ONLY blood tests are pedestrian, limiting and myth-leading…
Regrettably, Iron metabolism IS Graduate school Rocket Science! There is NOTHING that’s simple, or straight-forward about this central aspect of our bodies… I have been laboring tirelessly for 9 months now and am only beginning to understand the players, the components and how all this fits together and HOW the LACK OF UNDERSTANDING THIS has led to sooooo much metabolic dysfunction from the mineral dysregulation…
I do hope this offers up some KEEN insights about where to focus. I sincerely believe that Cp is, in fact, a MOUNTAIN and I see it as one… unlike the current fraternity of Iron researchers & practitioners seeking the support of their funders…
Here’s to our continued WISDOM re this Iron-ic dynamic!
A votre sante!
MORLEY M. ROBBINS
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