Some important clues:
o Cysteine Dioxygenase has an Iron atom at its core… And in the SAME way that Iron gets into the core of Hemoglobin, I’m assuming that it’s bioavailable Copper that enables THAT enzyme to work, as well… And when it doesn’t, then we have “Sulfate issues…”
o There is an entirely different pathway with Sulfite Oxidase (which relies on Molybdenum), but folks can have issues with Sulfates there, as well…
o Now, Rheumatoid Arthritis is one of the 30+ “Autoimmune Conditions” that have EXPLODED on the scene since the introduction of HFCS & GMO products, that coupled with the “enrichment of Flour with Iron filings, have created UNTOLD “Stress!” for our Livers, and caused a massive loss of Liver Copper and build-up of Liver Iron… (You might look into the work of Mary Fields, PhD in the early 1980’s…)
o Rheumatoid Arthritis = LOW Bioavailable Copper (& correspondingly, HIGH, Unbound Iron…)
o When Iron is out of control, and in a state of “overload,” it has a profound affect on both Magnesium status and TNFa:
— Mg deficiency is the metabolic PRECURSOR to the Inflammatory cascase triggered by Substance P — when intracellular Mg is too low: http://www.ncbi.nlm.nih.gov/pubmed/1384353
— Iron overload in the Liver has a devastating affect on Liver chemistry and CAUSES a rise in TNFa:
http://www.ncbi.nlm.nih.gov/pubmed/16890145
— And as you note later in this Thread, there is a decided impact of Sulfites on Thiamine (B1) status… And it turns out that Thiamine deficiency drives an increase in Iron:
http://www.ncbi.nlm.nih.gov/pubmed/3821175
(Man, oh man… Talk about a “Perfect Metabolic Storm!” ^^^^…)
There are hundreds (thousands?…) of articles that tie Mg Deficiency to Elevated TNFa and vice versa… Which is the Chicken, Which is the Egg?… An endless debate to some extent…
We are in TOTAL agreement re the impact of TOO LITTLE Mg… We just need to PULL THE CURTAIN BACK ALL THE WAY to reveal that Mg Loss is ALWAYS in response to a “Stressor!” It’s HOW we’re wired as a species…
As I study the cellular enzyme pathways, the impact of ROS (reactive oxygen species), the CENTRAL ROLE of Anti-oxidant Enzymes (produced in the Liver, btw) and the fact that LOW Ceruloplasmin ==> HIGH IRON STORED IN THE LIVER… Iron Stress is a cellular nightmare, esp. in the Liver… Iron is esp. TOXIC to Mg status in the Liver…
Given that ^^^^, I’m MORE inclined to say that the REAL THREAT is our exposure to Dietary & Supplemental Iron, which is further aggravated by the twisted and FALSE beLIEf that folks are “Iron Anemic…” OMg! MAG me with a spoon!…
In my world, based on my research and what I’ve been able to piece together from hundreds & hundreds of articles over 7 yrs of reading & reflection, the “Iron enriched wombs” of women today are producing children who are “Iron dysregulated,” and the agricultural, food & medical systems ONLY further that Iron-ic dysregulation. And Vaccines ONLY send this dysregulation into stratospheric orbit in a body that has LOW production of BOTH Copper-dependent Anti-Oxidant Enzymes, as well as LOW Maggie…
I am convinced that IRON is the 1st Offender, and Maggie is taking it on the chin — as she ALWAYS does — whenever we’re under “Stress!”
Hope that makes sense and connects some important mineral dots!
A votre sante!
MORLEY M. ROBBINS
